Leukemic and Cancer Stem Cells

 

Scientific Workshop on Leukemic and Cancer Stem Cells

DATES: April 26-28, 2013

LOCATION: Mandelieu, France

ORGANIZING COMMITTEE: D Bonnet, C Chomienne, P Valent
SCIENTIFIC COMMITTEE: M Andreeff, G Dontu, MH Lafage-Proust, MH Raaijmakers


EHA-ESH Scientific Workshops present state-of-the-art science. This workshop promotes informal interaction and discussion between scientists and clinicians working in the field.
The identification of cancer stem cells (CSC) in hematological diseases and in solid tumors, has led to the emergence of a new field in cancer research that is expected to provide insights into oncogenesis and hope for improved survival and cure. Recent research has highlighted the opportunity to target cells of the stem cell’s microenvironment. This workshop will provide the latest findings on the microenvironnement (bone, vasculature ...) of the normal and malignant stem cells and the tools to study the links between the stem cell and the cells of its microenvironement.

This workshop will cover the following topics:

  • Vascularisation and CSC
  • Tumor/CSC and Immunity
  • Skeletal and HSC niches in Bone
  • CSC and their niche
  • HSC/LSC and their niche
  • Solid Cancer Stem Cell and their niche
  • CSC and Metastasis
  • CSC/LSC and Hypoxia

 

Registration

Online registration will open through the website of the European School of Haematology: www.esh.org

Registration Fee*

Early Bird 560 euros
Regular (one month before the meeting starts) 695 euros
On site 795 euros

* Registration fee includes teaching material and lunch

CME Accreditation

The programme of the ESH-EHA Scientific Workshop on Leukemic and Cancer Stem Cells: Malignant Stem Cells and their Microenvironment has been reviewed and approved for CME accreditation by the European Hematology Association CME Unit. The EHA-CME Unit has approved this educational activity for a maximum number of CME credits. Each physician should only claim credits for time that she/he actually spent in the educational activity.

SPONSOR OPPORTUNITIES:

Several sponsor opportunities for this particular event have been created. For sponsor opportunities please contact Ghyslaine Lebougault at the European School of Haematology. Email: ghyslaine.lebougault@univ-paris-diderot.fr Telephone: + 33(0)1 57 27 67 39, Fax: + 33(0)1 57 27 68 38

Preliminary Program

Thursday, April 25, 2013

Time Title Speaker
13:30Opening and Welcome by the Organizing CommitteeP Valent , C Chomienne, D Bonnet
SESSION 1 – HEMATOPOIETIC STEM CELLS/LEUKEMIC STEM CELLS AND THEIR NICHE – Sponsored by NovartisChairs: J J Schuringa and F Louache
13:45-14:15 Regulation of normal and leukemic stem cell adhesion and migrationT Lapidot
14:15-14:45 Chronic Myeloid Leukemia stem cells and their niche R Bhatia
SESSION 2 - SOLID CANCER STEM CELLS AND THEIR NICHE Chairs: S Robine and R Galli
14:45-15:45Intestinal stem cells and their nicheJ P Medema
15:45-16:45Stem cells and their niche in the adult mammalian brain V Silva-Vargas
16:45-17:15 Coffee break
17:15-17:45 Symposium
17:45-18:45Short-Talk (5 best abstracts on hematopoietic stem cells/ cancer stem cells and their niche – 10 mns each)Chairs: M Raaijmakers and H Chneiweiss
19:30Dinner

 

Friday, April 26, 2013

Time Title Speaker
SESSION 3 - VASCULARISATION AND CANCER STEM CELLS Chairs: M Andreeff and T Enver
08:30-09:00Glucose metabolism in tumor microenvironment R Kalluri
09:00-09:30Instructive contribution of the vascular niche to homeostasis of normal and malignant stem cells S Rafii
SESSION 4 - SKELETAL AND HEMATOPOIETIC STEM CELL NICHES IN BONEChairs: M H Lafage Proust and M Goodhardt
09:30-10:00Role of the bone marrow envelope and capillaries in bone marrow-bone tissue interactions J M Delaisse
10:00-10:30Carcinomas and tumor-bone interactions P Clezardin
10:30-11:00Coffee break
SESSION 5 - EFFECT OF THE CROSS-TALK BETWEEN MICROENVIRONMENT AND CANCER STEM CELLSChairs: G Dontu and C Dosquet
11:00-11:30Hypoxia and glioblastoma cancer stem cells J Rich
11:30-12:00 Mesenchymal defect and epithelia tumors P Dotto
12:00-13:00Short talks from selected abstracts (5 Talks – 10 mns each)Chairs: G de Haan and S E Jacobsen
13:00-14:00Lunch
SATELLITE SYMPOSIUM – sponsored by Stem Cell Technologies
14:00-14:30Introduction to ALDEFLUOR Kit for the identification, evaluation and isolation of stem and progenitor cells expressing high levels of ALDHP Singh
14:30-15:00Targeting breast cancer stem cells C Ginestier
15:00-15:30Genotoxic consequences of endogenous aldehydes on mouse hematopoietic stem cell function J Garaycoechea
15:30- 17:15EuroCSCT short talks Chairs: C Chomienne and D Bonnet
Phenotypic characterization of Leukemic Stem Cells in Acute Myeloid Leukemia and Chronic Myeloid Leukemia P Valent
Differential role of polycomb repression complex 1 members in normal versus leukemic stem cellsJ J Schuringa
Tracing the fate of individual barcoded stem cellsG de Haan
Role of CXCR4 in MLL-ENL Acute Myeloid Leukemia F Louache
MDS stem cells: Functional and molecular properties and therapeutic surveillance S E Jacobsen
Targeting leukemia initiating cells in mutant NRAS/BCL-2 mouse models of MDS/AML progression R A Padua
Studying stem cell properties during colorectal cancer progression and disseminationS Robine
Molecular mechanisms governing the tumorigenic potential of brain tumor cancer stem cells R Galli
Heterogeneity in childhood leukemia T Enver
Glioma stem cells control their microenvironment : proteomic analysis H Chneiweiss
17:15-17:45Coffee break
17:30-18:30Best abstracts talks (10 mns each)Chairs: M Andreeff and M H Lafage Proust
18:30-19:00SATELLITE SYMPOSIUM – Sponsored by Miltenyi Biotec
Cancer stem cell targeting in advanced solid tumors - Introduced by C. ChomienneR de Maria
19:00-20:00Manned Poster Session
20:00Dinner

 

Saturday, April 27, 2013

Time Title Speaker
SESSION 6 - TUMOR/ CANCER STEM CELLS AND IMMUNITY Chairs: R A Padua and . Malanchi
09:00-09:30From cancer immune contexture to the Immunoscore J Galon
09:30-10:00Stromal cell niche in follicular lymphoma: more than a direct supportive effect K Tarte
SESSION 7 – CANCER STEM CELLS AND METASTASIS Chairs: D Dontu and R de Maria
10:00-10:30Breast cancer stem cells and metastasisI Malanchi
10:30-11:00Epithelial mesenchymal transition, cancer stem cells and metastasis C Scheel
11.00-12.00Special lecture - Introduced by D BonnetD Scadden
12:00Closing remarks - END OF MEETING

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