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What is Translational Research Training in Hematology?
Translational Research Training in Hematology (TRTH) provides junior researchers with a unique, year-long training and mentoring experience. TRTH is a joint effort of the European Hematology Association (EHA) and the American Society of Hematology (ASH) and is focused on helping early-career hematological scientists build successful careers in hematologic translational research. The TRTH program begins with an intensive week-long course held in the spring in Italy. Mornings are dedicated to didactic and interactive sessions which further participants understanding of translational research methodology and career development. Afternoons are devoted to small group sessions in which participants meet with their TRTH mentors, peers, and faculty to refine their individual research proposals. Informal presentations by leaders in hematology, designed to illustrate the variety of pathways to a successful career in hematology research, take place in the evenings.
TRTH aims to include participants at a specific stage in career development, namely being a trainee or junior faculty and hold an MD and/or PhD or biomedical PhD or pharmacy PharmD degree (or equivalents). Twenty early-career scientists are selected each year to participate in this rigorous training program. Please see the eligibility criteria in the dropdown menu below.
The faculty is made up of international leaders in hematology who cover biostatistics and biomarkers, genetics and molecular biology, ethics, and phase I clinical study design.
When do the meetings take place and what is the content?
The Spring Course will take place from March 11-17, 2017 in Italy.
The first follow-up meeting will take place during the 22 nd Congress of EHA in June 2017.
The second follow-up meeting will take place during the 59 th Annual Meeting of ASH in December 2017.
Both follow-up meetings will provide additional opportunities for participants to develop professional interaction with peers and mentors and refine their research proposals.
Principles of translational researchclick to expand
An overview of methodologies for designing and executing clinical research studies with laboratory correlatives will be presented. Topics will include stem cell research, animal models, live cell and in vivo imaging, flow cytometry, cell therapy, cell and biobanking, design of clinical trials, principles of bioinformatics, molecular pathogenesis including genetics, gene editing and epigenetics, pharmacogenomics, diagnostics and biomarkers, and identification of molecular targets.
Ethics in hematologic translational researchclick to expand
Discussions will focus on ethical and regulatory issues in Europe and North America related to translational research. Topics will include good clinical practice (GCP), quality care assurance, good manufacturing practice (GMP), relationships with the pharmaceutical and biotech industry, and intellectual property.
Career development insightclick to expand
Career retrospectives are provided from leading hematologists with a broad experience in translational research. Hematology pioneers will speak about their personal and career challenges and successes, and maintaining a work-life balance.
Small-group working sessionsclick to expand
Small working group sessions enables participants to refine their research projects with each other and with faculty. These sessions take place daily during the Spring Meeting and are an important part of the program, forging bonds for collaboration and in-depth improvements of your research proposal.
Presentation of research proposalsclick to expand
Participants will present their proposals at the beginning of the course; at the end, they will present revised proposals that incorporate the changes made throughout the week.
Learning objectives of the year-long programclick to expand
- Discuss the principles of translational research design and execution, including clinical trials with correlative science
- Recognize the ethical and regulatory issues of translational research.
- Examine the fundamentals of competitive grant writing, abstract presentation, and manuscript preparation.
- Demonstrate the improvements in the quality of their own research proposals through input from faculty and peers.
- Formulate strategies for pursuing and developing a successful career in hematological research.
- Discuss approaches to forming and sustaining a multi-disciplinary translational research team.
- Practice preparing research results and presenting your work to diverse audiences.
- Develop contact with other participants to facilitate future collaboration.
- Develop relationships with leaders in translational and clinical research who can enhance professional networking opportunities.
Eligibilityclick to expand
- Applicants must be a trainee or junior faculty and hold an MD and/or PhD or biomedical PhD or pharmacy PharmD degree (or equivalents).
- Eligible applicants are defined as applicants who at the time of their application and for the duration of the TRTH program are in hematology-related fellowship training are junior faculty or are program group leaders who have completed their fellowship training within the past three years. Fellowship training is defined as any sub-specialty training in hematology irrespective of whether this training is concurrent with another training program.
- Applicant must be actively employed in a hematology or hematology-related research environment.
- MD applicants must be within twelve years of post-graduation at the time of the deadline for full application. PhD applicants must have less than eight years of post-doc experience after graduation at the time of the deadline for full application. Applicants holding both an MD and a PhD must be within 12 years of MD-graduation. Exceptions may be made for interruptions in an applicant's academic pursuits; however, such circumstances must be explained by the applicant in the application.
- Both the applicant and the applicant's mentor must be EHA member or EHA Guest or ASH member at the time of LOI submission and throughout the term of the award program.
- Applicants from the same institution are eligible to apply; however, no more than ONE participant working in the same lab/research unit will be selected and no more than TWO participants from the same institution will be selected.
- Applicants with the same mentor are eligible to apply; however, no more than ONE participant from a specific mentor will be selected.
- Institution is defined as the institution where the applicant will be conducting research during the TRTH Program year, NOT the location of a prior mentor or a department head at an institution the applicant may return to later.
- Mentor is defined as the research supervisor at that institution.
- The focus of the TRTH program is on laboratory-based translational research. Research projects must be hypothesis driven and directly connected to some aspect of human biology. Projects may encompass any form of cellular, molecular, structural, biochemical, genetic, or other appropriate experimental approach using human biological material or human subjects with the aim of reaching novel insights into human biology. Pilot and early phase clinical studies translating the laboratory discoveries "to the bedside" may be included in the proposal; however, pure clinical trial projects with laboratory correlatives will not be considered.
- Proficiency in English is required.
Restrictionsclick to expand
- Applicants with certain professional credentials will not be considered, such as principal investigators, applicants holding more senior faculty positions, including being an established research group leader, and applicants who have obtained funding indicative of independent research status, tenure-track faculty with more than 2 years’ experience at this faculty level.
- TRTH is not designed for those with less than 1-2 years of postdoctoral research experience.
- Applicants working primarily on clinical research projects will not be considered.
- Applicants cannot be awarded for multiple career development opportunities in the same program year. Participation in the TRTH program in a certain year will disqualify the applicant for a Research award, CRTI program or other funding opportunities provided by ASH or EHA awarded in that particular calendar year. However, awards may be given to previous award winners in subsequent years. One can apply for these other opportunities a year after having participated in TRTH.
- Applicants who have been accepted to ASH's Clinical Research Training Institute (CRTI) program and are still within the CRTI program year are not eligible to apply for the TRTH program until after completion of the CRTI year.
- Applicants must be in the possession of a valid passport and permits that allow them to travel abroad.
Costsclick to expand
There is no registration or application fee, however, by applying, applicants agree that they will participate in all three meetings and respond to follow-up surveys in the future.
EHA and ASH arrange all travel and accommodation for the TRTH spring course and follow-up meetings as follows:
Travel, accommodation and food for the spring course are arranged and covered by EHA and ASH. Economy class airfare, up to € 1000, is arranged and covered by EHA and ASH. Participants are responsible for arranging their own VISA and valid travel documents in order to allow them to attend all TRTH Meetings.
Travel and accommodation for follow-up meetings are arranged and covered by EHA and ASH. Economy class airfare, up to € 1000 per meeting, is arranged and covered by EHA and ASH. Three nights accommodation, per follow-up meeting, are arranged in a designated hotel and covered by EHA and ASH.
The participant is responsible for additional hotel nights and airfare costs above the established allowable amounts. Additional details of the TRTH travel policy are communicated to awardees upon acceptance into the program.
If there are special circumstances regarding the participant’s or institute's ability to cover additional costs, applicants are still encouraged to apply. The mentor should include an addendum that explains the financial difficulties that exist.
Information for mentorsclick to expand
Please keep in mind when discussing this career development opportunity with your associates that applicants with the same mentor are eligible to apply; however, no more than ONE participant from a specific mentor will be selected.
If your associate is invited to submit a full application after the Letter of Intent has been evaluated, the following will be expected from you as mentor (NOT RELEVANT AT TIME OF INITIAL SUBMISSION):
- The applicant’s mentor must be a member of EHA and/or ASH and submit several
- Supervision and mentorship to be provided to the applicant during the TRTH award year.
- The mentor should describe the applicant’s abilities and likelihood to succeed in pursuing an academic career in translational research. The mentor must also indicate and detail his/her:
- Qualifications within the applicant’s research area, describing your previous experience in research training
- Commitment to providing a productive environment for the applicant to pursue the project.
- Indication of why/how TRTH will be beneficial to the applicant.
- Mentors Biosketch/CV (2-page limit) will be required, Including complete contact information, present position, training (including training in clinical and or translational research), publications, and other relevant information. The mentor’s documents will be evaluated based on the following: Mentor’s personal qualifications, Productivity and research support, as evidenced by the mentor’s CV/Biosketch, Mentoring experience and plans for mentoring and enhancing the career development of the applicant, environment for conducting the proposed research, A past history of the mentor working with the participant, the quality of that interaction may be included in the consideration of the mentoring plan.